Most 460's are truck engines and built more for torque than horsepower, so you probably wouldn't get a big horsepower gain. If you go to a 460, you should also change the transmission to one with big input and output shafts, and the tail shaft would have to be the right length for a Mustang. The driveline yoke will be different for the big output shaft. You'll need a different radiator, and should go heavier front springs for the extra weight. If you have Ram Air, the air cleaner is different, IIRC. For no real horsepower gain, putting the extra weight on the front end, which will affect handling, and the expense of changing everything else out, I wouldn't bother.
Steve