I think a rear turbo would add to the 'lag factor' of turbo charged engines as the compressed air has farther to travel.
The plumbing might cause some loss depending on the number of bends. Certainly will heat up the floor boards. Finally, you can't provide oil to the turbos back there (they must be sealed?) Oil from the engine typically also helps cool the turbo.
I think the more turbo successful installations would use a carb box setup (where the carb sits inside a pressurized box).
Carb has to be manual secondary (vacuum secondaries won't work in either blow through or boxed). Typically a differernt fuel pump is used that uses a hose to the manifold to sense the boost and increase fuel pressure.